Newbie reporter Meryl and veteran drunk Roberto chase after Vash the Stampede, the legendary "Humanoid Typhoon" with a huge bounty on his head. They don't have trouble finding him, but he appears much more low-key than they expected.
Despite being saved by Vash twice already, the townsfolk of Jeneora Rock decide it's in their best interest to capture Vash for his bounty. Vash decides to escape, but it's not just the gun-toting townsfolk he needs to run away from.
Vash, the town of Jeneora Rock, and the Nebraskas reach a three-way truce, but their brief moment of peace is shattered by yet another assailant. He seems to be after the plant as well, but something more sinister seems to be at play.
Vash is drawn towards a seemingly abandoned village with a giant windmill, for reasons that only he knows. There, the group is attacked by a tremendous gale of gunfire.
Vash and Wolfwood board the massive Sandsteamer vessel to travel to their final destination, JuLai. Yet again, they are ambushed by a hail of gunfire, but this time, it's someone Wolfwood knows.