On November 8, 2012, Lady Gaga released the original version of the song featuring her vocals, in which she performs the chorus and a verse.
"Bitch, Don't Kill My Vibe" peaked at number 32 on the United States Billboard Hot 100 chart, also reaching the top ten on the Hot R&B/Hip-Hop Songs and Hot Rap Songs charts.
On March 13, 2013, a snippet of the official remix for "Bitch Don't Kill My Vibe" featuring a guest appearance from American rapper Jay-Z was premiered by Jay-Z's engineer Young Guru.
Speaking to Rap-Up on March 9, 2013, Lamar stated that "Bitch, Don't Kill My Vibe" would probably be released as a single from Good Kid, M.A.A.D City.
Shortly after the premiere of the song's official remix, Lamar confirmed that "Bitch, Don't Kill My Vibe" would be the fourth official single.
