Prozac Nation

In an interview just before the film was finally released, former child star Christina Ricci, who was 20 at the time, admitted that doing her first nude scene ever in Prozac Nation was frightening. She said during production that director Erik Skjoldbjærg decided that a nude scene would show the character's complete emotional "nakedness," even though nudity wasn't in the script or even discussed before production began. Ricci agreed but requested a closed set and then she called her co-star Michelle Williams to come watch the monitor and let her know that everything looked okay. Afterward, Ricci was so relaxed with the nudity that she went on to perform nude scenes in several of her later films.

Elizabeth has a Bruce Springsteen "Tunnel of Love" album poster hanging in her room in 1985. The album was not released until 1987.

During the opening credits, the close-up shots of the letters Elizabeth is typing form the sentence, "I hate myself and I want to die."

Two versions are known to exist: the theatrical release, clocking in at 1h 35m (95 min) and the original Toronto International Film Festival (TIFF Canada) release, with a runtime of 1h 39m (99 min). The theatrical cut is significantly different from the original, having been subjected to numerous re-edits and test screenings by Miramax Films, which had acquired the distribution rights, and was eventually not given a general release to theaters. Screenplay co-writer Frank Deasy gave this opinion to "The Guardian" on why: "It's a truthful depiction of depression. And I think the reason Miramax has struggled is the fact that it doesn't have a traditional dramatic structure, in terms of a clear, unqualified ending. Look at the book: Elizabeth is very clear that Prozac has helped her, but you're left with a dilemma, because perhaps she no longer knows who she is. We didn't want to come down heavily on one side or the other. People who've experienced depression like that aspect of the film, but a lot of people don't like it. Miramax certainly don't seem to like it." The DVD release offers no information on the changes made from the original.