- She didn't know that Tim McGraw and Faith Hill were country superstars before shooting 1883 with them.
- She inspired Taylor Sheridan in creating the prequel of Yellowstone, 1883. Sheridan wrote 1883 script after he found Isabel auditioning for "Mayor of Kingstown". Thus, she didn't audition for her role as Elsa Dutton on 1883.
- She attended regular school through ninth grade, after which she was homeschooled. She secured her first job five months after leaving regular school.
- Alexa & Katie marked her debut role. She landed the lead role, named after the title, without any prior projects and with limited acting training.
- She had never ridden a horse before shooting 1883. However, other cast members of 1883 thought that she was a good horse rider.
- Got the role of Sidney Prescott's daughter in Scream 7 on her 24th birthday.
- Isabel May is an only child. Born and raised in Venice area, Santa Monica, Los Angeles.
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