- Defender for Newell's Old Boys (1988-93), Club Atlas (1993-96), River Plate (1996-00), Olympique de Marseille (1999), R.C. Celta Vigo (2000-05) and Cádiz CF (2005-06).
- Honours with Newell's Old Boys: Argentine League (1991, Clausura 1992). Honours with River Plate: Argentine League (Apertura 1996, Clausura 1997, Apertura 1997, Clausura 2000); Libertadores Supercup (1997).
- 13 appearances for the Argentina National Football Team (1996-2000). Member of the Copa América 1997 and 1999 squads.
- Father of, with Valeria, María Berizzo (b. 1996), Inés Berizzo (b. 1999) and Mateo Berizzo (b. 2002).
- Former Marcelo Bielsa's assistant in Chile National Football Team (2007-2010).
- Head coach of Estudiantes de La Plata (2011), O'Higgins F.C. (2012-14), R.C. Celta Vigo (2014-17), Sevilla F.C. (2017), Athletic Bilbao (2018) and Paraguay National Football Team (2019-).
- As a coach, he won the Chilean Primera División (2013 Apertura) and the Chilean Supercup (2014) with O'Higgins F.C..
- A prostate cancer survivor. (February 2018)
- In a relationship with Mariana Abumohor since 2014.
- Was classmates with Darío Franco.
- His mother (literature teacher) was also his teacher at high school.
- His father died in car accident in 2000.
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