- Daughter of Vincent D'Onofrio and Greta Scacchi. Half-sister of Matteo Mantegazza on her mother's side; Elias Gene D'Onofrio, born in December 1999 and Luka D'Onofrio, born on February 14, 2008 on her father's side. Stepdaughter of Carin van der Donk. Niece of Elizabeth D'Onofrio, Tom, Paul and Sarah Georgette Scacchi. Cousin of Hawk D'Onofrio. Granddaughter of Gene D'Onofrio.
- She filed for divorce on October 14, 2021, only a year after her wedding with Sean Penn.
- She has dual Australian and US citizenship.
- She is of Italian descent through both of her parents.
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