- Has two daughters, Matilda and Shanta.
- Two years after graduating college he co-founded a band called "The Comets." The Comets enjoyed brief popularity before he traveled to London in 1962.
- He received a grant from the Ghanaian government to study at a private music and drama school for three years, before being forced to leave by a regime change in Ghana.
- Founder and leader of the Afro-pop band Osibisa, founded in 1969.
- After graduating from college he worked as a building inspector for a year.
- A founding member and saxophone player for the iconic Afro-rock band "Osibisa".
- After graduating, Osei briefly worked as a building inspector before pursuing his musical dreams in London.
- While attending college in Sekondi, he formed his first band, "The Comets," with his friends.
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