- Has directed only three feature films, the last two of which have resulted in three of her actors receiving Oscar nominations: Melissa McCarthy, Richard E. Grant, and Tom Hanks.
- Has a son, Wylie Red Heller Taccone (b. December 12, 2014), with her husband Jorma Taccone.
- Her younger brother Nate Heller has composed the music for all three films Marielle has directed.
- Member of the 'Academy of Motion Picture Arts and Sciences' (AMPAS) since 2016.
- Graduated from UCLA.
- Sister of Emily Heller.
- Marielle Heller wanted to have a full frontal shot of the lead actress in "The Diary Of A Teenage Girl" but the actress didn't want to, possibly because of her comfort level.
- Sister-in-law of Asa Taccone.
- Daughter-in-law of Tony Taconne.
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