- Was inspired by his late father, a contractor, not to work in manual labor. Mackie's father later died in New Orleans due to Hurricane Katrina.
- Married his longtime girlfriend, Sheletta Chapital, in December 2014. They have four children together.
- He opened a bar called NoBar in Brooklyn, New York in the summer of 2011.
- He was roommates with Lee Pace at Juilliard.
- A graduate of The Juilliard School (Group 30).
- He enjoys skydiving and has done it six times.
- He appeared in two Best Picture Academy Award winners: Million Dollar Baby (2004) and The Hurt Locker (2008).
- Planned to be an engineer before falling in love with acting.
- His brother is an engineer in New Orleans, Louisiana who appeared in Spike Lee's documentary on Hurricane Katrina, When the Levees Broke: A Requiem in Four Acts (2006).
- Is currently (as of 2010) seeking a producer for a script he has about Olympic athlete Jesse Owens.
- His character in 8 Mile (2002) at one point has his rapping skills compared negatively to those of Tupac Shakur. 6 years later, Anthony played Tupac in Notorious (2009).
- Friends with Chadwick Boseman.
- Graduated high school from North Carolina School of the Arts with a concentration in acting.
- Attended New Orleans School for Creative Arts.
- Attended North Carolina School of the Arts, mid-90s.
- He has appeared in one film that has been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: The Hurt Locker (2008).
- A featured player in Regina Taylor's play, Drowning Crow, at the Manhattan Theatre Club. (January 2004)
- Performing Martin McDonagh's "A Behanding in Spokane" at the Schoenfeld Theatre on Broadway. (March 2010)
- Anthony Mackie considers Law and Order the worst acting moment in his career as the director does not speak English.
- As a kid, he took apart a lawnmower and built a go-kart.
- Hoped out of a plane backwards with US service (search and rescue) members.
- Unintentionally crashed a 13-year old's birthday party.
- Has spoken openly about having dyslexia, a learning disability that affected his school years and reading, which he noted actually pushed him toward acting. He has described struggling with reading, which requires him to take specialized steps to prepare for scripts.
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