- Was considered for the role of Freddy Kruger in A Nightmare on Elm Street (1984).
- Was in two movies that opened in the U.S. on the same weekend - The Battle of Shaker Heights (2003) and Jeepers Creepers 2 (2003) (August 29, 2003 - Labor Day Weekend).
- With TV commercials producer Kass McClaskey, he has a son Gannon McClaskey Wise (born 1985) and a daughter Kyna Wise (born 1987).
- Attended the 2011 Twin Peaks Festival. (August 2011)
- Profiled in "Character Kings: Hollywood's Familiar Faces Discuss the Art & Business of Acting" by Scott Voisin. (2009)
- Volunteered his time to make Pennyweight (1999), a short film shot in Portland, Maine. (1999)
- Has portrayed both the President of the United States in the game Command & Conquer: Red Alert 2 (2000), and the Vice-President of the United States in the show 24 (2001).
- No relation to director Robert Wise, despite a popular misconception.
- Lives in Glendale, California.
- Attended the 2010 Fall Hollywood Show in Burbank, California, which held a Twin Peaks (1990) reunion. (October 2010)
- Bears a resemblance to actor John Noble. Ironically, they also share the same birth date, August 20, though Ray is one year older.
- Brother-in-law of music editor Tass Filipos.
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