- A good friend of Zach Braff, he frequently appears in Braff's projects.
- He changed his last name from Rubinstein to Weston because there was already a Michael Rubinstein in the Screen Actors Guild.
- In July 2009, he guest-starred in the Burn Notice (2007) episode, Signals and Codes (2009). The show's main character shares his first and last name, although the fictional "Michael" spells his last name "Westen".
- Lived in Paris for a year and half with his grandmother after he graduated from college. While there, he worked as a bartender.
- Graduated from Northwestern University with a B.S. in theater arts.
- His father is of half Polish Jewish and half Polish Catholic background.
- When he was a teenager, he wanted to be a professional baseball player until he injured his arm playing baseball.
- Has twice played a role as an acquaintance of a Sherlock Holmes character: He was a private detective hired by House in 'House MD' and also a junkie "friend" of Jonny Lee Miller's version of Holmes in 'Elementary'.
- Although he shares the same last name with Celia Weston and also portrayed a character (Ross Niskar) who shares the same last name as Celia Weston's character (Arlene Niskar) in Adam (2020), the two Westons are not related.
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