- Spent four months as a cattle herder in Argentina trying to be "different". Afterward, he enrolled at Dublin's Trinity College, graduating in 1993 with a B.A. in English Literature. (1988)
- Was one of seven children (five girls, two boys) born to George and actress Moya (Cleary) West. His parents divorced in 1996.
- He has five children: his eldest daughter, Martha West with Polly Astor; and daughters Dora and Christabel and two sons, Senan and Francis, with wife Catherine FitzGerald.
- His maternal grandparents were Irish, and his paternal grandparents were English and Irish.
- Dominic West portrayed late author George MacDonald Fraser's Victorian anti-hero Harry Flashman, the main character of Fraser's "Flashman" novels, at an auction of Fraser's library. West also stated at the time that he would like to see a new Flashman movie made for the new generation. The only previous movie, Royal Flash (1975), was not a success, and was so disliked by Fraser that he would not allow another one to be made in his lifetime. (2014)
- Attended Eton College, Berkshire. Also schooled there, though two years behind, was Band of Brothers (2001) and Life (2007) star Damian Lewis.
- Began appearing in community theatre at age nine.
- He was sighted kissing and holding hands with English actress Lily James, raising questions about his marital status. However, on 13 October, both Dominic and his wife Catherine emerged from their home, kissed for the onlookers and media who had gathered out front, and made a short statement. They said their marriage was strong and that they were very much still together before handing out a piece of paper with the statement written on it and signed by both of them individually. (October 2020)
- He is a first cousin, once removed, of American politician Thomas Eagleton, who was briefly the 1972 Democratic nominee for Vice President of the United States. Dominic's paternal great-grandparents, Thomas Francis Eagleton and Mary Theresa Hennelly (who had moved to Missouri from Ireland), were also the paternal grandparents of politician Eagleton.
- Met wife-to-be Catherine FitzGerald while both were students at Dublin's Trinity College in Ireland.
- Graduated from Guildhall School of Music and Drama. (1995)
- He and his wife renovated her inherited Glin Castle in Ireland, where they live most of the year and rent rooms to tourists.
- Appearing as Jan in the play "Rock & Roll" at the Duke of York Theatre in London, England. (February 2007)
- Son-in-law of Olda FitzGerald.
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