- Founded the Tamarind Lithography Workshop, where leading artists collaborated with professional printers to create high-quality prints. The Workshop was named after the street where she lived at the time of its founding, Tamarind Street (Hollywood, California).
- She dropped out of high school in Chicago, Illinois to pursue art.
- She was married to George Wayne, a United States Army Air Corps flight surgeon. In 1941, she moved to Los Angeles, California where she studied production illustration in a program jointly run by California Institute of Technology in Pasadena, California and Art Center School but returned to Chicago, Illinois to work as a scriptwriter for the radio station WGN. She returned to Los Angeles, California after World War II ended in 1945.
- She is survived by her daughter, Robin Claire Park of Poulsboro, Washington; a stepdaughter, Abby Moore of Tucson, Arizona; and two grandchildren.
- She founded Tamarind Lithography Workshop in 1960 in Los Angeles, California. In 1970, Tamarind Workshop was taken over by the University of New Mexico and renamed the Tamarind Institute.
- She was a Distinguished Visiting Research Professor (2002-2007) at Rutgers University in New Brunswick, New Jersey. In 1997, she was the artist in residence at the Brodsky Center at Rutgers in New Brunswick, New Jersey. There is a June Wayne Archive and Study Room based on her gift of 3,321 prints (2,555 from Wayne herself).
- She is survived by her granddaughters, Ariane Junah Claire and Jevon Claire.
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