- Ex-stepdaughter of Marsha Mason and Diane Lander.
- Niece of Danny Simon.
- Sister of Nancy Simon.
- Stepdaughter of Elaine Joyce.
- Has a son Andrew Simon Leland (B. December 16, 1980) with her first husband John Leland and a daughter Sofia Lola Florimbi (B. December 20, 1992 in Los Angeles ) with her third husband Michael Florimbi.
- Ellen and sister Nancy Simon are married to brothers: Ellen's husband is Michael Florimbi and Nancy's husband is David Florimbi. Both couples have been married since 1992.
- Daughter of playwright Neil Simon and Joan Baim.
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