- Son of a Polish underground fighter who survived the Sachsenhausen concentration camp.
- Older brother of Nina Siemaszko.
- Trains in the martial arts: Hapkido, Judo and Tai Chi. He is also a serious Zen student.
- Competes in Olympic distance triathlons and plays League Soccer.
- Graduated from the Goodman School of Drama at DePaul University in Chicago, which his sister, Nina Siemaszko, later attended along with another alum, Gillian Anderson.
- Brother of Corky Siemaszko, a reporter/writer for the New York Daily News.
- His last name is pronounced "Shye-mash-ko."
- Was once roommates with Stand by Me (1986) co-star and actor, Gary Riley.
- Portrayed Joey Stivic in the first episode of the short-lived final All in the Family (1971) spin-off, 704 Hauser (1994). Ironically, Rob Reiner, who played Mike Stivic, the father of Joey, in All in the Family (1971), directed Stand by Me (1986), in which Casey Siemaszko appeared in.
- He is of Polish descent on his father's side and English descent on his mother's.
- Born on exactly the same date as Dana Reeve.
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