- On May 12, 2014, Sherri filed for divorce from her second husband of three years, Lamar Sally after discovering multiple infidelities and him living a double life. In social media posts, she has referred to him as a "con artist".
- Initially, Sherri was expecting twins, but the girl passed away in utero, and she ended up in giving birth only a boy, Jeffrey, three months prematurely.
- Sherri and her son, Jeffrey Tarpley Jr., share the same birthday.
- Her debut book, "Permission Slips: Every Women's Guide to Give Herself a Break" was released in 2009. Her second book, "Plan D: How to Lose Weight and Beat Diabetes" was released in 2013 and made The New York Times Bestsellers list.
- Has two sons: Jeffrey Tarpley Jr. (b. April 22, 2005) with first ex-husband, Jeff Tarpley and Lamar Sally Jr. (b. August 5, 2014) with second ex-husband, Lamar Sally.
- She was born in Chicago and attended Winston Churchill Elementary School and Eisenhower Junior High School of Community Consolidated School District 54 and Hoffman Estates High School of District 211.
- Her first stand-up comedy CD/DVD, "No Refund, No Exchange" was released in 2006. Her second comedy special "It's My Time to Talk" was taped in Arizona and aired on the EPIX channel in 2013.
- She was awarded a Star on the Hollywood Walk of Fame for Television at 6258 Hollywood Boulevard in Hollywood, California on November 3, 2025. Walk of Fame inductees Tyler Perry and Niecy Nash were guest speakers at the ceremony.
- She appeared on the May 1, 2009 episode of WWE Smackdown! (1999) as the guest manager for MVP.
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