Albert Brooks, John Lithgow, Leslie Mann, Melissa McCarthy, Paul Rudd, and Jason Segel in This Is 40 (2012)

Neil Patrick Harris, Alyson Hannigan, Jason Segel, Josh Radnor, and Cobie Smulders in How I Met Your Mother (2005)

Amy Adams and Jason Segel in The Muppets (2011)

Rashida Jones, Paul Rudd, and Jason Segel in I Love You, Man (2009)

Alyson Hannigan and Jason Segel in Bad News (2011)

Jason Segel and Lukita Maxwell in Shrinking (2023)

Harrison Ford and Jason Segel in Shrinking (2023)

Amanda Peet and Jason Segel in How I Met Your Mother (2005)

Amanda Peet, Alyson Hannigan, and Jason Segel in How I Met Your Mother (2005)

Jason Segel and Jessica Williams in Shrinking (2023)

Linda Cardellini and Jason Segel in Freaks and Geeks (1999)

Alyson Hannigan and Jason Segel in How I Met Your Mother (2005)

Adrien Brody, DeVaughn Nixon, Jason Segel, Delante Desouza, Austin Aaron, Jimel Atkins, and Quincy Isaiah in Winning Time: The Rise of the Lakers Dynasty (2022)

Adrien Brody and Jason Segel in Winning Time: The Rise of the Lakers Dynasty (2022)

Jason Segel in Winning Time: The Rise of the Lakers Dynasty (2022)

Tracy Letts and Jason Segel in Winning Time: The Rise of the Lakers Dynasty (2022)

Mila Kunis, Kristen Bell, Jason Segel, and Russell Brand in Forgetting Sarah Marshall (2008)

Kristen Bell, Jason Segel, and Russell Brand in Forgetting Sarah Marshall (2008)

Devon Sawa, Jason Schwartzman, Jaime King, Michael C. Maronna, Laura Prepon, and Jason Segel in Slackers (2002)