- Her daughter Paloma "Pippa" has Down Syndrome.
- She has a BA from the University of Toronto.
- For her role on Private Practice (2007) as Dr. Amelia Shepard, she was introduced to Shonda Rhimes by the director/actor Eric Stoltz, who had worked with her ten years before and remembered that she resembled Patrick Dempsey. She won the role and is now a regular on the series.
- Her ancestry is Italian (father) and Swedish, English, and Scottish (mother).
- She is a qualified canoe instructor and also enjoys kayaking and swimming.
- Mother, with her now estranged husband Rob Giles, of daughters Eliza Giles (b. July 6, 2012), Paloma ''Pippa'' Michaela Giles (b. November 8, 2016) and Arwen Lucinda ''Lucky'' Giles (b. December 2019).
- Younger sister of twins Francesca Scorsone and Jovanna Scorsone.
- Has appeared in every production by producers William Laurin and Glenn Davis since their CBS pilot Shock Treatment (1995).
- (May 9, 2020) Has filed for divorce from her husband of 10 years Rob Giles.
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