- Jimmy Santos is known for Rocky n Rolly: Suntok sabay takbo (1990), Bondying: The Little Big Boy (1989) and Electrika kasi, eh! (1977).
- Popularized "Carabao English" in his comedy films in the 90s. "Carabao English" is a Filipino slang term for broken, grammatically incorrect English or literal direct translations from Tagalog to English. For veteran comedian and TV host Jimmy Santos, it was his signature comedic trademark.
- In mid-70s, ha joined Philippine show business, playing as extra in few movies before being typecast as character actor playing as a goon. In 1980s, he ventured into comedic roles. He got his first lead role in I Love You Three Times a Day (1988). He was one of the top comedian in the 90s.
- He was one of the host of Eat Bulaga (1979) from 1983 until 2022.
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