- Best remembered for his role as Ernie in Scarface (1983).
- Was a friend of Al Pacino.
- Achieved notice playing Loren Lukas in the controversial 1980 film Cruising (1980) directed by William Friedkin.
- Acting career took a nose-dive when the handsome, muscular Santana gained over 100 pounds and became a heavy-set character actor.
- Was an altar boy at Our Lady of the Light Catholic Church. Ironically, his funeral service was at the same church.
- Studied acting at the American Conservatory Theater (A.C.T.) school in San Francisco, California in the mid 1970s.
- Attended the University of Texas at Austin.
- Graduated from Burges High school.
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