- Was mentored by actor Mark Ruffalo at the beginning of his career.
- Has two children: daughter Nina Sadoski (Nina Seyfried Sadoski) (born March 21, 2017) and son Thomas Seyfried Sadoski (born 2020) with wife Amanda Seyfried.
- Nominated for the 2009 Tony Award for Best Performance for a Leading Actor in a Play for "Reasons to Be Pretty".
- On November 29, 2016, Thomas and his then fiancee, Amanda Seyfried, announced they were expecting their first child in spring 2017; three days later, during a different interview with W magazine, Amanda unintentionally revealed they were expecting a son. The W magazine interview appeared in the January 2017 issue. However, the revelation turned out to be incorrect.
- At Williamstown Theatre Festival, he was given the nickname "Lots o' lips".
- His father is of one half Polish, one quarter Swedish, and one quarter English (with distant Welsh), ancestry. His mother is of half Italian and half German descent.
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