- Mary Lou Rosato is of Italian ancestry.
- She was awarded the 1979 Joseph Jefferson Award for Actress in a Principal Role in a Musical for "The Curse of the Aching Heart" at the St. Nicholas Theater Company in Chicago, Illinois.
- She was nominated for a 1980 Joseph Jefferson Award for Actress in a Principal Role in a Play for "The Primary English Class" at the St. Nicholas Theater Company in Chicago, Illinois.
- She was awarded the 1996 Drama Logue Award for Outstanding Performance for "Changes of Heart" at the Mark Taper Forum Theatre in Los Angeles, California.
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