- Romero's studio website Artie.com received more than one billion hits in a 20-month period in 2005-2006.
- At San Diego Comicon in 1979, Artie Romero spilled beer on Monkey Punch's pants. (Japanese manga artist Kazuhiko Kato).
- Romero was briefly suspended from Mitchell High School in Colorado Springs, Colorado in January, 1969 for selling copies of his first comic book, Platinum Toad #1, in the hallways of the school.
- Romero was adopted by his stepfather in 1962, and his last name was changed from Thomas to Romero on his birth certificate. At that point the "Junior" in his name was dropped.
- In 2005, Romero redesigned the National Day of Prayer website for President George W. Bush and Shirley Dobson, Chair of The National Day of Prayer Taskforce. Romero's mission was to prevent server crashes that had been a problem in previous years. Romero was successful in keeping the site online.
- In 2022, clips from the first episode of Romero's 1983-84 TV miniseries Video Game All Stars were licensed to be included in Pause and Replay, a series of films about the history of video games, on public display in the Smithsonian Institution's National Museum of American History.
- On September 13, 2003, Romero climbed Pikes Peak during a blizzard. The occasion was The Pikes Peak Challenge, an annual fundraiser for the Brain Injury Association of Colorado. Romero was the last of 300 climbers to reach the top, and was welcomed to the Summit House by Olympic Gold Medalist Picabo Street.
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