- Started as a stand-up comic when he was 13.
- Due to his deep voice and bulky frame, he has always appeared old for his age. When he was doing stand-up in his teens, he was often thought to have been in his 20s, and at the age of 22, he convincingly played a 30-something character in The 40-Year-Old Virgin (2005).
- The Vancouver Aquarium named an octopus (cephalopod) after him-Ceph Rogen.
- Seth Rogen auditioned for a lead role in Dude, Where's My Car? (2000).
- According to "Rotten Tomatoes", his five favorite films are: The Big Lebowski (1998), Ghostbusters (1984), The Last Detail (1973), Total Recall (1990) and GoodFellas (1990).
- Good friends with Jay Baruchel.
- His parents met each other in Israel.
- As a child, Rogen attended Camp Miriam, a Jewish summer camp on Gabriola Island, British Columbia, Canada. He also studied for and had his Bar Mitzvah, the coming-of-age service that Jewish boys celebrate at age 13.
- His production company (Point Grey Pictures) is named after the neighborhood, he grew up in, in Vancouver, Canada.
- Engaged to Lauren Miller Rogen [September 29, 2010].
- Is left-handed.
- He has appeared in one film that has been nominated for the Best Picture Oscar: The Fabelmans (2022).
- Was ranked #20 on Entertainment Weekly's '30 Under 30' the actors list. (2008).
- Attended Point Grey Secondary School in Vancouver with future business partner Evan Goldberg.
- In Pineapple Express (2008), in the scene where he is arrested by the police officer, his height is listed as 5' 9".
- Son of Mark Rogen and Sandy Rogen. Has an older sister, Danya Rogen.
- Appeared in a TV talent show. (1996)
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