- Ke Huy Quan's film debut was in Indiana Jones and the Temple of Doom (1984). An open casting call was put out to all the elementary schools to find a young Asian actor to play Short Round. Quan arrived with his brother, not to audition, but merely to provide moral support. He caught the casting director's attention because he spent the entire time of his brother's audition telling him what to do and what not to do. Steven Spielberg liked his personality, so he and Harrison Ford improvised the scene where Short Round accuses Indy of cheating during a card game. Quan won the role over about 6,000 other auditions.
- Holds a second-degree black belt in taekwondo; he began taking classes after learning from a taekwondo instructor for his role in Indiana Jones and the Temple of Doom (1984).
- Close friends with his The Goonies (1985) co-star Jeff Cohen, also his entertainment lawyer.
- Was on the Time 100, a list of the 100 most influential people in the world by Time magazine, with an homage penned by English actor and feminist Tom Hiddleston. (2023)
- Speaks Cantonese, Mandarin, Vietnamese and English fluently.
- Childhood friends with actress-producer Drew Barrymore.
- Was invited to join the Academy of Motion Picture of Arts and Sciences (AMPAS) (Actors Branch) 2023.
- Good friends with Academy Award winner Michelle Yeoh.
- Ranked #67 in VH1's 100 Greatest Kid Stars (2005).
- Currently resides in Woodland Hills, Los Angeles, California.
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