18 wins & 55 nominations
- 2008 Winner Primetime Emmy
- Outstanding Guest Actress in a Drama Series
For playing "Janis Donovan". For episode: "Alternate". - 2005 Nominee Primetime Emmy
- Outstanding Lead Actress in a Miniseries or a Movie
For playing: "Eleanor Roosevelt". - 2004 Winner Primetime Emmy
- Outstanding Supporting Actress in a Comedy Series
For playing "Miranda Hobbes". - 2003 Nominee Primetime Emmy
- Outstanding Supporting Actress in a Comedy Series
For playing: "Miranda Hobbes". - 2002 Nominee Primetime Emmy
- Outstanding Supporting Actress in a Comedy Series
For playing: "Miranda Hobbes".
- 2006 Nominee Golden Globe
- Best Performance by an Actress in a Miniseries or a Motion Picture Made for Television
- 2004 Nominee Golden Globe
- Best Performance by an Actress in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television
- 2003 Nominee Golden Globe
- Best Performance by an Actress in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television
- 2001 Nominee Golden Globe
- Best Performance by an Actress in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television
- 2023 Nominee Satellite Award
- Best Actress in a Supporting Role in a Series, Miniseries, Limited Series or Motion Picture Made for Television
- 2016 Nominee Satellite Award
- Best Actress in a Miniseries or a Motion Picture Made for Television
- 2005 Nominee Satellite Award
- Outstanding Actress in a Miniseries or a Motion Picture Made for Television
- 2003 Nominee Golden Satellite Award
- Best Actress in a Supporting Role in a Series, Comedy or Musical
- 2018 3rd Place NSFC Award
- Best Actress
Tied with Frances McDormand for Three Billboards Outside Ebbing, Missouri (2017) in 3rd place.
- 2024 Nominee Actor
- Outstanding Performance by an Ensemble in a Drama Series
Shared with: Erin Wilhelmi · John Douglas Thompson · Morgan Spector · Douglas Sills · Jeremy Shamos · Blake Ritson · Taylor Richardson · Harry Richardson · Patrick Page · Kelli O'Hara · Kristine Nielsen · Donna Murphy · Debra Monk · Audra McDonald · Robert Sean Leonard · Matilda Lawler · Nathan Lane · Celia Keenan-Bolger · Sullivan Jones · Simon Jones · Louisa Jacobson · Ward Horton · Jack Gilpin · David Furr · Taissa Farmiga · Kelley Curran · Carrie Coon · Michael Cerveris · Nicole Brydon Bloom · Denée Benton · Christine Baranski · Ashlie Atkinson · Ben Ahlers - 2006 Nominee Actor
- Outstanding Performance by a Female Actor in a Television Movie or Miniseries
- 1987 Nominee Young Artist Award
- Exceptional Performance by a Young Actress, Supporting Role in a Feature Film - Comedy, Fantasy or Drama
- 2016 Nominee Critics' Choice TV Award
- Best Actress in a Movie Made for Television or Limited Series
- 2015 Nominee Critics' Choice TV Award
- Best Supporting Actress in a Movie/Limited Series
- 2008 Nominee INOCA TV
- Best Guest Actress in a Drama or Comedy Series
2019 Winner British LGBT Award- LGBT+ Celebrity
- 2025 Nominee Ambie
- Best Performance in Audio Fiction
Shared with: Jesse James Keitel · Jane Lynch · Sarah Steele · Bowen Yang · Ian McKellen · Shannon Woodward · Sara Ramirez · Raúl Esparza · Joel Kim Booster
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