- Twin sister of Wendy Melvoin.
- Daughter of L.A. studio musician Michael Melvoin.
- Sister of one-time Smashing Pumpkins touring keyboard player Jonathan Melvoin. (Jonathan played keyboards during the 1996 touring cycle of Mellon Collie & The Infinite Sadness, where he died of a heroin overdose July 12, 1996 in Manhatten, New York).
- Melvoin is reported to be the subject of Prince's song "Nothing Compares 2 U", made famous by Sinéad O'Connor's cover.
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