- Masterson was the subject of a whole chapter in William Goldman's 1969 book "The Season: A Candid Look at Broadway." The book covered a single season (1967-68) in Broadway theater; the chapter focusing on Masterson recounts his experiences starring in the 1967 play "The Trial of Lee Harvey Oswald" (written by Amram Ducovny and Leon Friedman); the play only ran for 3 previews and 9 performances, and was considered a flop. Later in their lives, children of both Masterson and Ducovny became acting stars: Masterson's daughter Mary Stuart Masterson (Fried Green Tomatoes) and Ducovny's son David Duchovny ("The X-Files").
- In 1979, was nominated for two Tony Awards for "The Best Little Whorehouse in Texas:" as Best Director (Musical,) along with collaborator Tommy Tune, and as Best Book (Musical), along with Larry L. King.
- He was nominated for a 1976 Joseph Jefferson Award for Actor in a Principal Role for his performance in "That Championship Season", at the Arlington Park Theatre in Chicago, Illinois.
- Cousin of writer Horton Foote.
- Attended Rice University.
- He has appeared in two films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: In the Heat of the Night (1967) & The Exorcist (1973).
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