- Was considered for the role of Indiana Jones in Raiders of the Lost Ark (1981).
- In order to get the proper creepy and raspy voice for his performance as Billy in Black Christmas, Mancuso would stand on his head to compress the thorax in his neck.
- Nick Mancuso reprised his role as Billy's voice for an audio commentary as his character for the 40th anniversary Blu-ray release of Black Christmas.
- Moved to Canada in 1956.
- In 1983 he was invited to become an associate of the Actors Studio by co-chairman, actor, Martin Landau.
- He started his acting career in the mid-1960s as a founding member of several independent theaters in Toronto, such as Toronto Free Theatre, Canadian Stage, Factory Lab Theatre, and Theatre Pass Muraille.
- He performed in plays at Canada's prestigious Stratford Festival in 1976, in the leading role of Bassanio in "The Merchant of Venice", as well as in "Antony and Cleopatra" and "A Midsummer Night's Dream", working with Maggie Smith, Jessica Tandy and Hume Cronyn.
- In 1979 he made his American stage debut working directly with one of America's greatest playwrights, Tennessee Williams, for Tiger Tail and Night of the Iguana in Atlanta, Georgia.
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