- Before getting the part of T-Bag in Prison Break (2005), he considered becoming a park ranger to support his family, due to the 'phasing out of the middle-class actor'.
- During the filming of Hitman (2007), his Danish co-star Ulrich Thomsen jokingly confided in him that his last name, "knepper", is in fact a dirty word in Danish.
- Robert studied drama in Northwestern University (1977-1981).
- Graduated from Maumee Highs School in Maumee, Ohio. Was the class of 1977.
- Robert and Tori are parents of a boy named Benjamin Peter Knepper (Ben Knepper).
- He had the tenor solos in the "Messiah" his senior year at Maumee High School.
- He was awarded a 1982 Joseph Jefferson Award Citation for Actor in a Principal Role in a Play for "Class Enemy" at the Next Theatre Company in Chicago, Illinois.
- He lives with his family in Los Angeles.
- He is of mostly German descent, with smaller amounts of Swiss-German, English, and Scottish ancestry.
- Son of a veterinarian in real-life, his character "T-bag" on Prison Break (2005) has a twisted encounter with a veterinarian in Season 1.
- Mother: Pat Deck (died in 2003).
- Father: Donald Knepper.
- Appears in the Jellyfish music video for The Ghost of Number One as the drug and fame addicted rock star.
- Ex-son-in-law of Peter V. Herald.
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