- Started My Favorite Murder, a true crime podcast, in January 2016 with good friend and television personality, Georgia Hardstark. The podcast has been praised by Rolling Stone, LA Weekly, and Huffington Post among others as one of the best new podcasts of 2016.
- Comedian Margaret Cho extended special thanks to her in her book, I'm the One That I Want (2001). Karen and Margaret became good friends while doing stand-up in San Francisco in the early 90's.
- Quit drinking alcohol after being diagnosed with a seizure disorder in the 1990's.
- Hates driving to/from LAX, but co-hosts a podcast called "Do You Need a Ride" with comedian Chris Fairbanks where the platform includes driving a guest (often a fellow comedian) to/from the airport while recording each episode.
- Close friends with actors Patton Oswald and Guy Branum.
- Member of the Girls Guitar Club with Mary Lynn Rajskub.
- Her maternal and paternal grandparents emigrated to California from Ireland when they were teenagers.
- Admitted she auditioned for Jerry Maguire (1996) hungover while a guest on the Walking the Room podcast hosted by Greg Behrendt and Dave Anthony.
- Her father was a San Francisco fireman and her mother was a psychiatric nurse (RN).
- Started performing stand-up comedy in Sacramento and later San Francisco in the early 1990s.
- Used to have a cat named Angus who did party tricks.
- Karen shows a genuine concern for mental health, recognizing its importance and working towards raising awareness and supporting those who are affected.
- Was raised Roman Catholic.
- One of her favorite movies is Michael Clayton (2007).
- Moved to Los Angeles in 1994.
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