- Author of science fiction and nonfiction. His novel Flowers for Algernon has never gone out of print.
- The short story version of "Flowers for Algernon" won the Hugo Award in 1960. The novel version won the Nebula Award in 1966. (It tied with Samuel R. Delany's novel Babel-17 for the Nebula Award.) Keyes also won a Special Author Emeritus award in 1999.
- Was on the English faculty at Ohio University until he moved to Florida.
- The Milligan Wars, a continuation of The Minds of Billy Milligan, has never been published the United States.
- He served in the U.S. Maritime Service, then earned a bachelor's degree in psychology from Brooklyn College, where he also received a master's degree in American literature.
- He taught in New York schools, and later was a professor at Wayne State University in Detroit and at Ohio University in Athens.
- Lives in Southern Florida. (April 2003)
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