- Earned a Master's degree in journalism from NYU in 1997.
- Before pursuing an acting career, Regina once worked as a waitress at a "Twin Peaks" restaurant, a job she loved. She also worked for a time as a dental assistant, a job she hated.
- Graduated from Fordham University in 1992.
- Appeared in three films with Sanaa Lathan: The Best Man (1999), Love & Basketball (2000), and Disappearing Acts (2000).
- In 2006 she was living with Sanaa Lathan while her house was being renovated.
- She played Coretta Lipp in the drama "Ally McBeal"; in "Scary Movie 2", her character made fun of "Ally" star Calista Flockhart.
- Is from the same metro area as Martin Lawrence, Alan Heitz, Dave Chappelle, Mya, Sandra Bullock, and Dwayne Winstead.
- Contributed vocals on rapper Sadat X's "Wild Cowboys" album on the track "The Interview.".
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