- Daughter of Kelsey Grammer and Doreen Alderman.
- Named after her ill-fated aunt who was raped and murdered eight years before she was born. Her middle name, Karen, is the same as her late aunt's first name.
- Mother, Doreen Alderman, was a back-up dancer (dressed in green) in Steve Martin's Saturday Night Live (1975) King Tut skit.
- Once had an alpaca named Frasier; now has a cat named Cookie.
- She has one son name Emmett Emmanuel Hesketh (b. October 10, 2011) with her ex-husband James Hesketh.
- Younger half-sister, Greer Grammer, was Miss Teen Malibu 2008.
- Has six younger half-siblings through her father Kelsey Grammer: Greer Grammer (b. February 15, 1992), Mason Olivia Grammer (b. October 24, 2001), Jude Gordon Grammer (b. August 28, 2004), Faith Evangeline Elise Grammer (b. July 13, 2013), Kelsey Gabriel Elias Grammer (b. July 22, 2014) and Auden James Ellis Grammer (b. November 14, 2016). And one half-sibling Madison Skinner on her mother's side.
- Wanted to be a zoologist as a child.
- Studied art history at Marymount Manhattan before switching to theater.
- Attended college at Marymount Manhattan.
- (November 30, 2017) Her husband of 6 years James Hesketh has filed for divorce from her.
- Attended Los Angeles County High School for the Arts.
- One of her favorite movies is Annie Hall (1977).
- When she was 10 years old, she had a crush on Jonathan Taylor Thomas.
- Engaged to James Hesketh [January 25, 2011].
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