Nathan Fillion, Michelle Monaghan, and Jimmy Bennett in Trucker (2008)

Neil Patrick Harris, Nathan Fillion, Simon Helberg, and Felicia Day in Dr. Horrible's Sing-Along Blog (2008)

Nathan Fillion and Summer Glau in Serenity (2005)

Adam Baldwin, Nathan Fillion, Gina Torres, Morena Baccarin, and Summer Glau in Serenity (2005)

Adam Baldwin, Nathan Fillion, Ron Glass, Sean Maher, Jewel Staite, Gina Torres, Alan Tudyk, Morena Baccarin, and Summer Glau in Firefly (2002)

Vin Diesel, Nathan Fillion, Gina Torres, and Summer Glau in The Chronicles of Riddick (2004)

Keri Russell and Nathan Fillion in Waitress (2007)

Geena Davis and Nathan Fillion in Geena Davis & Nathan Fillion (2026)

Shawn Ashmore, Nathan Fillion, Richard T. Jones, Eric Winter, Jenna Dewan, Alyssa Diaz, Melissa O'Neil, Mekia Cox, Lisseth Chavez, and Deric Augustine in The Rookie (2018)

Nathan Fillion, Edi Gathegi, and Isabela Merced in Superman (2025)

Vondie Curtis-Hall and Nathan Fillion in The Recruit (2022)

Dina Meyer and Nathan Fillion in Castle (2009)

Nathan Fillion and Stana Katic in Castle (2009)

Nathan Fillion and Alan Tudyk in An Alien in New York (2022)

Nathan Fillion and Alan Tudyk in Old Friends (2022)

Pete Davidson, Nathan Fillion, Sean Gunn, Michael Rooker, Joel Kinnaman, Flula Borg, Jai Courtney, Margot Robbie, and Mayling Ng in The Suicide Squad (2021)

Nathan Fillion and Mekia Cox in The Overnight (2020)

Nathan Fillion and Mekia Cox in Follow-Up Day (2020)

Nathan Fillion and Mekia Cox in Warriors and Guardians (2019)

Nathan Fillion and Richard T. Jones in Impact (2019)

Nathan Fillion, Richard T. Jones, Eric Winter, Alyssa Diaz, Melissa O'Neil, and Titus Makin Jr. in The Rookie (2018)

Nathan Fillion and Afton Williamson in The Rookie (2018)