Co-writer of the screenplay for the 1982 neo-noir science fiction film Blade Runner and its 2017 sequel Blade Runner 2049, based on the novel Do Androids Dream of Electric Sheep? by Philip K. Dick.
In 2019, Fancher published The Wall Will Tell You, a screenwriting manual which drew from his personal experiences.
At 15, he ran away to Spain to become a flamenco dancer and renamed himself "Mario Montejo".