- His inspiration for Bender was Slim Pickens from "Blazing Saddles" and his friend from college, who would do improvisations of an old man who liked sausage.
- Not related to Joe DiMaggio.
- Is a very talented beatboxer, as seen by some of his work on Futurama.
- Is the only one of two actors to play the same fictional character (Bender Bending Rodriguez) on both The Simpsons (1989) and Futurama (1999) the other is Nancy Cartwright who played Bart in both, although several people (including Conan O'Brien, Leonard Nimoy, Nichelle Nichols, Stephen Hawking and Dick Clark) have played themselves on both series.
- Married to actress Kate Miller 10/2014.
- Once performed stand-up comedy at the famed Apollo Theater in Harlem.
- Played Steve Ballmer in Pirates of Silicon Valley (1999).
- Italian-American.
- He and Kevin Michael Richardson have both voiced the Joker and Lobo from DC Comics.
- Grew up in North Plainfield, NJ.
- He is a lifelong Democrat.
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