- Granduncle of Janina Gavankar.
- Maternal uncle to author and director Nilu N. Gavankar. Nilu directed the shelved film Aankhon Mein Sapne Liye starring Janina and Samraat Mukherjee. Nilu is also the sister of Pete Gavankar (father of actress Janina Gavankar).
- Mangesh's maternal nephew Pete Gavankar is the father of world famous journalist and former Miss District of Columbia 1997, Sonya Gavankar.
- Maternal nephew Pete (Ganesh ) Gavankar produced Rahul Dev Burman's International album Pantera.
- Brother of documentary editor Sadanand Desai.
- Related to Vasant Desai .Mangesh is Vasant's nephew.
- Son Deepak Desai is a surgeon in Mumbai.
- In one of the most iconic scenes of Sholay (1975), Amitabh tosses the coin in the pre-climax and the stereophonic sound of the coin travelling from on one to another, was completely designed by Mangesh Desai.
- Mangesh Desai brought a bagghi (Horse Cart) in the sound studio to record the sound for Dhanno in the very crucial chase scene of Sholay.
- In Kamal Amrohi's Paakeezah it was Mangesh Desai's idea to include the whistle of a train in the closing part of the classic song "Chalte Chalte Yoonhi Koi Mil Gaya Tha".
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