- Does the voice of Donkey in Shrek (2001) and Shrek 2 (2004) in Latin American Spanish. Also does the voice of Mushu in Mulan (1998) in Latin American Spanish.
- To this day, holds the record for the highest rating for a non-episodic series episode in Mexican TV history, which went to his parody of the series Baywatch. The episode reached a 48.0 rating high, a number usually reserved for World Cup matches and telenovela series finales.
- He was awarded a Star on the Hollywood Walk of Fame at 7013 Hollywood Boulevard in Hollywood, California on March 10, 2016. Rob Friedman, Co-Chairman of Lionsgate Motion Picture Group, was a guest speaker at the ceremony.
- He used to own a Formula Renault team along with Israel Jaitovich.
- Son of Eugenio González Salas, a publicist, and Silvia Derbez, an actress. The surname Derbez, from his maternal grandfather, originates with French ancestry.
- His son Vadhir Derbez played the younger version of his character in How to Be a Latin Lover (2017).
- Has a daughter, Aitana Derbez Rosaldo (b. August 4, 2014), with his wife Alessandra Rosaldo.
- Invited to join the actor's branch of the Academy of Motion Picture Arts and Sciences (AMPAS) in 2018.
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