- Sister of Madonna, Martin Ciccone, Anthony Ciccone, Christopher Ciccone and Melanie Henry. Half-sister of Mario and Jennifer Ciccone.
- In the 1980s, was roommates with Jorja Fox.
- Aunt of Lourdes Leon and Rocco Ritchie.
- Sister-in-law of Joe Henry, husband of her sister Melanie.
- Step-daughter of Joan Ciccone.
- Daughter of Silvio Ciccone and Madonna Fortin.
- Distant relative of Céline Dion. They share the same French-Canadian heritage through a common ancestor, Zacharie Cloutier.
- Former sister-in-law of Sean Penn and Guy Ritchie.
- She's of Italian descent on her father side, and French Canadian on her mother side.
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