- Sang the 1987-1991 opening of long-running ABC soap opera, One Life to Live (1968).
- Has had 7 hit songs all duets with some of the most prominent female artists in the industry. He won two Grammys in less than two years for two of his 7 duets both songs appeared on Disney soundtracks for Aladdin and Beauty and the Beast in 1992 and 1993 respectively.
- Friends with Bill Withers.
- His tax problems caught up with him on August 21, 2003, when the U.S. Internal Revenue Service seized property from his home in Atlanta, Georgia. He is reported to have owed $1.2 million in taxes dating back to 1984. The IRS auctioned many of his possessions, including both Grammy Awards, electronic equipment, his grand piano and multiple pairs of shoes. However, his Grammy for "A Whole New World (Aladdin's Theme)" was purchased by a close friend of the family who vowed to return it to Bryson.
- Bryson's love for music stemmed from his mother, who often took the family to concerts of well-known black artists at the time.
- Co-host, with Angela Martinez, of an infomercial for TimeLife's "Classic Soul Ballads" music collection. (2006)
- Has three grandchildren: Marrissa Summer Bryson, John Alexander Thigpen, Jr. and Candace Jaleigh Thigpen.
- Has one son.
- On April 29, 2019, it was reported that Bryson had suffered a heart attack, and had been taken to an Atlanta hospital, where he was said to be in a stable condition. He made a full recovery.
- He spent much of his childhood on his grandfather's farm in Mauldin, South Carolina.
- On September 4, 2016, it was declared "Peabo Bryson Day" in Charleston, South Carolina and North Charleston, South Carolina, during the LowCountryJazzFest. The annual jazzfest is presented by ClosingTheGapInHealthCare.org, founded by Dr. Thaddeus Bell.
- Has one daughter, Linda.
- Bryson was engaged several times to Juanita Leonard, the former wife of boxing great Sugar Ray Leonard. In the 1990s, he became engaged to Angela Thigpen, former Miss Virginia Teen USA and later a model/actress.
- In early 1998, Bryson contributed his voice to Barney's Great Adventure: An Original Motion Picture Musical Soundtrack, with the song "Dream (Twinken's Tune)".
- Bryson performed in theater and operatic productions, most notably the tenor role of "Sportin' Life" in the Michigan Opera Theater of Detroit's version of Porgy and Bess.
- He left home to tour the Chitlin' Circuit with another local band, Moses Dillard and the Tex-Town Display. Bryson's first break came during a recording session at Atlanta's Bang Records. Although Bang was not impressed with Dillard's band, the young backup singer caught the ear of the label's general manager, Eddie Biscoe. Biscoe signed Bryson to a contract as a writer, producer, and arranger and encouraged Bryson to perform his own songs.
- Bryson marked his professional debut at the age of 14, singing backup for Al Freeman and the Upsetters, a local Greenville group. It was Freeman's difficulty in pronouncing Bryson's French West-Indian name, Peapo, that led Bryson to perform as Peabo.
- In 2002, Bryson's "Beauty and the Beast" music video was included on the platinum and Blu-ray edition of Beauty and the Beast. His "A Whole New World" music video was included on the platinum edition DVD release of Aladdin. Bryson's CD Missing You was released on October 2, 2007, on Peak Records, a division of Concord Music Group.
- In 2000 he participated in the International competition in the 41th International Festival of the Song of Viña del Mar where he won the international competition representing France, earning the Gaviota (Givet) of Gold in that contest. In 2001 he was invited as a jury to the Festival.
- In 1976, he launched his own recording career with "Underground Music" on the Bang label. His first album, Peabo, followed shortly thereafter. Although only a regional success, Bryson signed to Capitol Records in 1977.
- Before marrying his wife, singer and member of English R&B group The 411, Tanya Boniface, Bryson was engaged several times. First to Juanita Leonard, the former wife of boxer Sugar Ray Leonard. In the 1990s, he became engaged to Angela Thigpen, former Miss Virginia Teen USA and later a model and actress.
- After collaborating with singers Luther Vandross and Cissy Houston on his debut album Peabo (1976), he signed to Capitol Records and released the 1978 albums Reaching for the Sky and Crosswinds, which were certified Gold by the Recording Industry Association of America (RIAA).
- Bryson's greatest solo hits include 1977's "Feel the Fire" and "Reaching for the Sky", 1978's "I'm So into You" and "Crosswinds", 1982's "Let the Feeling Flow", 1984's "If Ever You're in My Arms Again" (his first Top 10 pop single, at No. 10 in the US), 1989's "Show and Tell", and the 1991 hit "Can You Stop the Rain".
- He released the collaborative projects We're the Best of Friends (1979) with Natalie Cole and Born to Love (1983) with Roberta Flack, the latter of which included the hit single "Tonight, I Celebrate My Love".
- Parents are: Marie Bryson, and Telford Copeland.
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