- Second Mexican to be nominated for a Best Actor Oscar. The first was Anthony Quinn.
- Sent a bottle of white tequila to each of his fellow nominees for Best Actor in the 2012 Academy Awards.
- He provided the Latin American Spanish voices of: Aladdin in Aladdin (1992), The Return of Jafar (1994) and Aladdin and the King of Thieves (1996), Prince Eric and Chef Louis in The Little Mermaid (1989), Tulio in The Road to El Dorado (2000) and Apollo Blue in Jetsons: The Movie (1990).
- His parents took his name from the Herman Hesse novel 'Demian: The Story of Emil Sinclairs Youth'.
- Has played two famous Latin American revolutionaries: Fidel Castro in Che: Part One (2008) and Che: Part Two (2008) and Emiliano Zapata in "Zapata: Amor en rebeldia" (2004).
- Brother of Bruno Bichir and Odiseo Bichir.
- Has a daughter, Gala.
- Born on the same date as John Carroll Lynch.
- Brother in law of Yolanda Ventura.
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