- He created Tom and Jerry, Huckleberry Hound, The Flintstones and also worked on The Smurfs (1981).
- With partner William Hanna, departed Metro-Goldwyn-Mayer Cartoon Studios to begin Hanna-Barbera Productions.
- Born on the East Coast, he started his career in animation at the Van Beuren Studios. When Amadee J. Van Beuren closed, he was able to go to Rochester and get a job with Paul Terry (Terrytoons). He moved to the west coast when Metro-Goldwyn-Mayer Cartoon Studios offered him a job with a substantial raise in pay.
- Longtime partner of William Hanna.
- Had two younger brothers: Lawrence Barbera (1909-1982) and Theodore Barbera (1911-1994).
- Had three children: Neal Barbera, Jayne Barbera and Lynn Barbera, from his first marriage.
- Before becoming an animator, he worked in banking and as a magazine illustrator. He also tried his hand at amateur boxing and playwriting. He sold a sketch to Collier's magazine who then encouraged him to become a cartoon artist. Barbera began his career on the East Coast but eventually ended up in California at Metro-Goldwyn-Mayer Cartoon Studios, where he met Hanna.
- He and William Hanna were awarded a Star on the Hollywood Walk of Fame for Television at 6753 Hollywood Boulevard in Hollywood, California.
- Inducted into the Television Academy Hall of Fame with his creative partner William Hanna (1994).
- In 1957, Hanna-Barbera Productions formed their own production company and sold their first new cartoon, The Ruff & Reddy Show (1957), to television.
- Following his death, he was entombed inside a Mausoleum crypt at Forest Lawn Memorial Park in Glendale, California. Its funeral home supplied his casket. His passing occurred four months prior to what would have been his 96th birthday on March 24, 2007.
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