- Although he is probably best known for playing bully Biff Tannen in the Back to the Future (1985) trilogy, he is said to be a very nice man in real life who drew upon his own personal experiences of being bullied as a child to create the Biff persona.
- As a recurring character on Ghost Whisperer (2005), he returned to the same set he acted on during the Back to the Future (1985) trilogy.
- He paints many portraits of classic children's toys. He was selected to join the California Featured Artists Series at Disneyland (2006).
- He was awarded the 1991 Saturn Award for Best Supporting Actor as Buford "Mad Dog" Tannen in Back to the Future Part III (1990).
- Studied international business at Arizona State University in Tempe, Arizona.
- Attended and graduated from Radnor High School in Radnor, Pennsylvania (1977).
- Attended the American Academy of Dramatic Arts (AADA) in New York City.
- Says that the car scene in Back to the Future (1985) where he molests the Lea Thompson character, Lorraine, was the most difficult scene he ever shot. In between takes, he would whisper, "I'm so sorry, Lea", to which she would reply, "It's just acting, Tom.".
- Has three daughters (Anna May, Emily, and Grace) and a son (Thomas Francis III) with Caroline Wilson. He was married three days after Back to the Future (1985) premiered.
- He made guest appearances on both Lois & Clark: The New Adventures of Superman (1993) and Superman: The Animated Series (1996).
- Has appeared in an episode of the comedy series Psych (2006) entitled "Let's Get Hairy" and in a movie called Let's Get Harry (1986).
- Is often mistaken by fans for the late character actor David Graf who played Tackleberry in the Police Academy movies. Many fans think Wilson played Tackleberry, unaware that it was in fact Graf and Graf actually passed away in 2001.
- Often received fanmail meant for Tom Wilson, creator of the Ziggy comic strip.
- Good friends with actor Marc McClure.
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