7 wins & 25 nominations
- 1990 Winner American Comedy Award
- Funniest Supporting Female Performer in a TV Series
- 1975 Nominee Daytime Emmy
- Outstanding Actress in a Daytime Drama Special
For episode "The Girl Who Couldn't Lose (#3.4)".
- 1992 Winner Primetime Emmy
- Outstanding Voice-Over Performance
For playing "Marge, Patty, Selma and Marge's Mother". For episode "I Married Marge". - 1990 Nominee Primetime Emmy
- Outstanding Individual Performance in a Variety or Music Program
For "Parallel Existence (My Better Whole)"/"The Man That Got Away"/ "The Co-Op". - 1989 Nominee Primetime Emmy
- Outstanding Individual Performance in a Variety or Music Program
For "Ginny vs. Roz"/"Dance Studio"/"The Simpsons". - 1988 Nominee Primetime Emmy
- Outstanding Individual Performance in a Variety or Music Program
For episode "Drugs and Guns". - 1987 Nominee Primetime Emmy
- Outstanding Individual Performance in a Variety or Music Program
- 2004 Winner Young Artist Award
- Most Popular Mom & Pop in a Television Series
Shared with: Dan Castellaneta
2024 Winner OFTA TV Hall of Fame- Actors and Actresses
- 2015 Nominee BTVA Television Voice Acting Award
- Best Vocal Ensemble in a Television Series - Comedy/Musical
Shared with: Dan Castellaneta · Nancy Cartwright · Yeardley Smith · Hank Azaria · Harry Shearer · Tress MacNeille · Pamela Hayden · Maggie Roswell · Russi Taylor - 2014 Nominee BTVA Television Voice Acting Award
- Best Vocal Ensemble in a Television Series - Comedy/Musical
Shared with: Dan Castellaneta · Nancy Cartwright · Yeardley Smith · Harry Shearer · Hank Azaria · Tress MacNeille · Pamela Hayden · Maggie Roswell · Marcia Wallace - 2013 Nominee BTVA Television Voice Acting Award
- Best Female Lead Vocal Performance in a Television Series - Comedy/Musical
As the voice of "Marge Simpson".
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