- He is nearly a foot taller than his father John Cassavetes. He got his height from his mother's (Gena Rowlands) side of the family.
- Is a gifted speed-reader.
- Considers The Notebook (2004) his worst film.
- Older brother of actors Xan Cassavetes and Zoe R. Cassavetes.
- Grandson of Katherine Cassavetes and Lady Rowlands.
- Met Heather Wahlquist shortly before filming John Q (2002). While on set, they fell in love and got engaged one month later. They have one child together.
- Was in negotiations to write a screenplay for a remake of his father's film, The Killing of a Chinese Bookie (1976) for New Line Cinema with Brett Ratner set to direct in 1998. The project never got made because Ratner made The Family Man (2000) instead.
- Alumnus of the AADA (American Academy of Dramatic Arts), Class of 1980.
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