Rob Lowe and Andrew McCarthy in Brats (2024)

Tom Cruise, Emilio Estevez, and Rob Lowe in Brats (2024)

Rob Lowe, Judd Nelson, Ally Sheedy, Phil Donahue, and Richard Schickel in Brats (2024)

Demi Moore, Emilio Estevez, Rob Lowe, Andrew McCarthy, Judd Nelson, Ally Sheedy, and Mare Winningham in Brats (2024)

Rob Lowe and Gina Torres in 9-1-1: Lone Star (2020)

Rob Lowe, Gina Torres, Mike Kopera, Jim Parrack, Julian Works, Brianna Baker, and Natacha Karam in 9-1-1: Lone Star (2020)

Rob Lowe, Gina Torres, Jim Parrack, Julian Works, Brianna Baker, and Natacha Karam in 9-1-1: Lone Star (2020)

Rob Lowe, Gina Torres, and Jim Parrack in 9-1-1: Lone Star (2020)

Rob Lowe and Jill Renner in 9-1-1: Lone Star (2020)

Rob Lowe and Jim Parrack in 9-1-1: Lone Star (2020)

Rob Lowe and Andy Favreau in 9-1-1: Lone Star (2020)

Rob Lowe, Giselle Bonilla, and Tu Do in The Musical (2026)

Emilio Estevez, Rob Lowe, and Judd Nelson in Brats (2024)

Rob Lowe and Donald Sutherland in Salem's Lot (2004)

Rob Lowe, Martin Sheen, Allison Janney, Dulé Hill, Moira Kelly, Richard Schiff, John Spencer, and Bradley Whitford in The West Wing (1999)

James Cromwell, Rutger Hauer, Rob Lowe, Samantha Mathis, and Andre Braugher in Salem's Lot (2004)

Rob Lowe and Jim Belushi in Living in Peril (1997)

Rob Lowe, Max Morrow, and Kimberly Williams-Paisley in The Christmas Shoes (2002)

Robert Duvall, Rob Lowe, William H. Macy, Aaron Eckhart, Maria Bello, and Katie Holmes in Thank You for Smoking (2005)

Sally Field, Rob Lowe, Calista Flockhart, Balthazar Getty, Rachel Griffiths, Sarah Jane Morris, John Pyper-Ferguson, Matthew Rhys, Ron Rifkin, Emily VanCamp, Patricia Wettig, and Dave Annable in Brothers & Sisters (2006)